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The Multipurpose Applied Physics Lattice Experiment (MAPLE), later renamed MDS Medical Isotope Reactors (MMIR), was a dedicated isotope-production facility built by AECL and MDS Nordion. It was intended to include two identical reactors, as well as the isotope-processing facilities necessary to produce a large portion of the world's medical isotopes, especially molybdenum-99, medical cobalt-60, xenon-133, iodine-131 and iodine-125. An operational license for the MAPLE 1 reactor was granted in 1999, and the reactor went critical for the first time soon after. However, problems with the reactor, most notably a positive power co-efficient of reactivity, led to the cancellation of the project in 2008.